Knockdown and overexpression experiments with SC lines, including NF1-associated malignant peripheral nerve sheath tumor cells, NF1-heterozygous deficient SCs, and NF1-deficient plexiform neurofibroma cells, to target Forkhead box M1 (FOXM1), a classical proliferation-associated transcription factor, showed that FOXM1 could mediate human malignant peripheral nerve sheath tumor development and could be a promising therapeutic target for tumor treatment [540]. This evidence concerns the gene NF1 and plexiform neurofibroma.