Exosomal miRNA-21-5p from human SCs (i) increased the proliferation, motility, and invasiveness of several human non-small cell lung cancer (NSCLC) cell lines in vitro by targeting metalloprotease inhibitor RECK in tumor cells and (ii) augmented human lung cancer cell progression and lymph node metastasis in vivo [639]. This evidence concerns the gene RECK and non-small cell lung carcinoma.