SYNE2 and Emery-Dreifuss muscular dystrophy: EDMD2, the most represented form of EDMD, is caused by LMNA gene mutations [2], EDMD1 is linked to EMD gene encoding the inner nuclear membrane protein emerin [3], and EDMD4 and EDMD5 are associated with mutations in SYNE1 or SYNE2 genes, respectively, encoding nesprin 1 or 2 [4].