SOD1 and amyotrophic lateral sclerosis: To understand the potential of this scFv to bind ALS-relevant misfolded SOD1 in CNS tissue, we tested this misfolded hSOD1 scFv antibody for binding by IHC in spinal cord samples from transgenic NSG mice expressing G93A hSOD1 (mSOD1-NSG) and non-transgenic littermates (NTL).