PLCG2 and age-related macular degeneration: Ma et al. identified an 81-gene signature enriched in glial markers that predicted AMD status and overlapped with known AMD gene loci, reinforcing the genetic basis of glial involvement They also discovered a novel AMD-associated variant, rs4133124 at PLCG2, suggesting that genes involved in retinal glial function may drive AMD’s pathology and that disease progression may not follow a strictly linear course [97].