Truncation of the N-terminal domain caused Autosomal Dominant EDMD (AD-EDMD)—a neurogenic variant—and two different constructs of the N-terminal-truncated lamin C. In the first construct, eight amino acids were deleted from the rod domain in addition to the lack of the N-terminal domain [133]. The gene discussed is LMNA; the disease is Emery-Dreifuss muscular dystrophy.