indicated a pro‐survival role for XBP1s through modulation of the nuclear factor‐kappa B (NF‐κB) pathway in breast cancer.[13] In addition, a positive regulatory feedback loop was identified between XBP1s and ER signaling.[14] Therefore, XBP1s has received extensive attention and is considered a promising therapeutic target in breast cancer. The gene discussed is NFKB1; the disease is breast cancer.