However, tumor cells often overexpress glucose transporter 1 (GLUT1) and hexokinase 2 (HK2), leading to excessive glucose uptake and depletion of extracellular glucose, which limits mTORC1 activation in effector T cells and impairs their proliferation and interferon‐γ (IFN‐γ) production. The gene discussed is HK2; the disease is neoplasm.