The shift toward aerobic glycolysis in tumor cells has profound effects on immune cell function.[70] Activated CD8+ and CD4+ T cells rely heavily on glycolysis to fuel mechanistic target of rapamycin complex 1 (mTORC1) signaling, drive Myc‐ and hypoxia‐inducible factor‐1α (HIF‐1α)‐mediated transcriptional programs, and support the biosynthesis necessary for clonal expansion and cytokine production. Here, CD8A is linked to neoplasm.