General transcription factor IIi (GTF2I) is the most abundant interactor of IGH::DUX4 in REH cells - an ALL cell line - but not in the other cells types, and CUT&Tag analysis showed selective binding of GTF2I to DUX4-r target genes in REH cells even in the absence of IGH::DUX4. This evidence concerns the gene GTF2I and acute lymphoblastic leukemia.