Under various pathological conditions like inflammation and viral infection, elevated plasma levels of TF were observed, leading to diffused thrombosis which can result in microvascular occlusion and organ dysfunction.16,17 It is also reported that TF on monocyte/macrophage plays a critical role in initiating thrombosis in those conditions.18,19 Although recent reports hinted at the existence of soluble TF proteins under certain pathological conditions, the origin of these soluble TF proteins and their thrombogenic properties remain elusive.20 The gene discussed is TF; the disease is viral infectious disease.