CASP3 and Familial prostate cancer: This pattern is consistent with studies on LKEENRRRRD from Sepia esculenta, which exhibited antiproliferative effects against prostate cancer cells by activating p53 and caspase-3-mediated apoptosis61, and supports previous findings that R. venosa-derived compounds increase TP53, CASP3, AIFM1, and BAX expression, promoting apoptotic induction via mitochondrial pathways29.