CASP3 and breast cancer: These findings align with previous studies showing that R. venosa hemolymph triggered p53-dependent pathways in human breast cancer cells30 and are consistent with marine peptides like ILYMP from Cyclina sinensis, which induced apoptosis in prostate cancer cells via upregulating BAX/BCL2 ratio and activating caspases 3 and 9-mediated apoptosis59.