Intranasally administered Apolipoprotein A, which facilitates removal of excess cholesterol and leads to caveolae reorganization, had anti-inflammatory effects, possibly dependent on IL-33 inhibition and decreased expression of the epithelial mucus gene Muc5ac, an epithelial cytokine which can promote eosinophilic inflammation in the airways55. Here, MUC5AC is linked to inflammatory response.