Moreover, inflammation and oxidative stress are critical contributors to PCOS pathology, with decreased antioxidant defenses [reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT)] while, increased malondialdehyde (MDA), Cyclooxygenase-2 (COX-2), and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) levels, contributing to disease progression3,4. The gene discussed is NFKB1; the disease is polycystic ovary syndrome.