Inspecting the top markers for each of these variables, we observe common genes for all three variables such as IDH1, IDH2, ATRX, PIK3CA, and EGFR (Fig. 4B), which could be explained by the fact that the clinical variables such as age and histological subtype are correlated with the survival outcomes of the patients, underpinning the importance of these genes in the etiology of the gliomas, which have been extensively studied and reported before24. Here, IDH2 is linked to central nervous system cancer.