To confirm that the induction of autophagy via EUDAL and STAT3 affects drug resistance in vivo, tumor-bearing mouse models were established by inoculating parental HN4/HN6, HN4/HN6 EUDAL wt, HN4/HN6 EUDAL Del-mut, parental CAL-27/HN30, and CAL-27/HN30 EUDAL KD cells. Here, STAT3 is linked to neoplasm.