To further identify the critical site through which circSMPD4 influences LDHA acetylation, we generated LDHA‐knockout tumor cell lines (HepG2‐R LDHA‐KO and Huh7‐R LDHA‐KO) (Figure S6G, Supporting Information) and referenced the mass spectrometry results from an outstanding study. This evidence concerns the gene LDHA and neoplasm.