LDHA and neoplasm: Notably, tumor cells prefer to perform Warburg metabolism, characterized by lactate production even in the presence of oxygen.[17] Elevated LDHA expression has been observed in various tumor tissues and correlates with poor prognosis in several malignancies.[21, 22, 23, 24, 25] Current evidence suggests that LDHA level is primarily regulated through transcriptional and posttranscriptional mechanisms,[26, 27, 28, 29] with limited research on posttranslational regulation, particularly in HCC.