Notably, an authoritative study had reported that LDHA can be degraded through the CMA‐lysosomal pathway in pancreatic cancer.[54] CMA involves the molecular chaperone heat shock cognate 71 kDa protein (HSC70/HSPA8) recognizing and binding a specific motif on substrate proteins, facilitating their transport into lysosomes for degradation, while LAMP2A plays a crucial role in regulating CMA flux.[55] shRNA‐mediated LAMP2A silencing reversed LDHA downregulation caused by circSMPD4 knockout (Figure 5H), supporting our hypothesis. This evidence concerns the gene LDHA and familial pancreatic carcinoma.