The HBV core protein (HBc) plays a crucial role in HBV replication and has cytopathic effects associated with severe hepatitis, making it a promising therapeutic target for HBV infection and HBV infection related liver diseases.[5, 6] Once HBV pre‐genomic RNA (pgRNA) is transcribed from covalently closed circular DNA (cccDNA), HBc will be translated from pgRNA, and some HBc will be assembled into nucleocapsids. The gene discussed is KRT88P; the disease is liver disorder.