Mishra et al. [15] showed that ALS-CSF infusion induces a strong disorganization and a reduction in the levels of neuronal intermediate filaments in the spinal cord, including Nf light chain (NfL), that could be linked to selective translational suppression of NfL mRNA due to TDP-43 proteinopathy [52]. The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.