Few years ago, our group reported that the i.c.v. infusion of CSF from sALS patients in mice expressing human TDP-43 wild type (hTDP-43WT) induced within 14 days ALS-like phenotypes, including motor and cognitive deficits, TDP-43 proteinopathy, Nf disorganization and neuroinflammation [15]. The gene discussed is TARDBP; the disease is Cognitive impairment.