Significant differences between PVS and controls were identified for otolin-1 (SMD, 1.53; 95% CI, 0.95 to 2.12), 25-OH vitamin D (SMD, -0.47; 95% CI, -0.76 to -0.19), C-reactive protein (SMD, 0.86; 95% CI, 0.35 to 1.37), leukocyte counts (SMD, 0.45; 95% CI, 0.18 to 0.72), neutrophil counts (SMD, 0.85; 95% CI, 0.44 to 1.25), and the neutrophil-to-lymphocyte ratio (SMD, 0.80; 95% CI, 0.48 to 1.12).<h4>Conclusions</h4>Inner ear-specific protein (otolin-1) and inflammatory markers (e.g., CRP, fibrinogen, leukocyte/neutrophil counts, and NLR) demonstrated potential diagnostic utility for PVS. This evidence concerns the gene CRP and perivascular space measurement.