A substantial agreement between raters was found in visually interpreting tau subtypes (κ > 0.65, p < 0.001) and a fair agreement between visual and automated subtypes (κ = 0.39, p < 0.001), with the automated approach more likely to classify a scan as tau negative and lower agreement between methods in more severe cases and AD clinical variants. This evidence concerns the gene MAPT and Alzheimer disease.