Although this study was conducted in Malawi, the findings of elevated levels of maternal-derived rotavirus-specific IgG interfering with oral rotavirus vaccine (ORV) immunogenicity, suboptimal vaccine-induced IgA responses in early infancy, and an increase in rotavirus-associated infections and seroconversions beyond six months of age, are consistent with patterns reported in other LMICs [13,21,23,24,49,50]. Here, CD79A is linked to infection.