The observed discrepancy between the upregulation of HDAC6 at 6 hours post-infection with PEDV or PDCoV in our study (Fig 2A–2C) and the downregulation after 12 hours or more post-infection with PDCoV [28] could be attributed to the stage of infection, as our study collected cells at the 6-hour time point, and to the cell type, as the elevated level of HDAC6 was weaker than that observed in IPEC-J2 and ST cells. Here, HDAC6 is linked to infection.