Selected oxygen tensions reflect the BM in MM, as evidenced by increased HIF-1α stabilization and activity8, 9, 10,13, 14, 15 (which occurs below 3%-5% O25, 6, 7), physiological oxygen levels in the lymph node (5% O2), and atmospheric oxygen levels (21% O2), under which T-cell activity has typically been studied. The gene discussed is HIF1A; the disease is Miyoshi myopathy.