Manipulation of IL1 signaling in state‐of‐the‐art in vitro decidualized endometrial organoids impacts epithelial differentiation, and in an in vivo endometriosis model, treatment with anakinra (an interleukin‐1 receptor antagonist) results in a significant, dose‐dependent reduction in spontaneous and evoked pain and dampened pro‐angiogenic signaling. Here, IL1A is linked to endometriosis.