HRH1 and diabetic kidney disease: In a murine model of streptozotocin-induced diabetic nephropathy, the blockade of the histamine H4 receptor by JNJ39758979 (100 mg/kg/day) [45] and the blockade of the histamine H1 receptor by bilastine (30 mg/kg/day) [46] have been shown to reduce renal damage induced by diabetes.