In the event of anaphylaxis, epinephrine injections are the core treatment, supplemented with antihistamines, glucocorticoids, and β-agonists inhalations.4 Immunotherapy has shown promise as a treatment for wheat allergy, but has yet to be established in clinical practice.4 Non-IgE–mediated eosinophilic gastrointestinal diseases can be treated by avoidance of the triggering agent as well as drug therapy (for eosinophilic esophagitis: proton pump inhibitors, vonoprazan, and glucocorticoids; for eosinophilic gastroenteritis: antihistamines, leukotriene inhibitors, and glucocorticoids).48 The gene discussed is IGHE; the disease is eosinophilic gastrointestinal disease.