CP and melanoma: Here, we provide for the first time a detailed insight into the mechanism of action of a platinum(IV) complex based on the cisplatin (CP) scaffold bearing two deprotonated NSAID ligands (naproxenate (Npx)) in axial position ([CP(Npx)2]), free and immobilized in nanostructured silica SBA-15 (SBA-15|[CP(Npx)2]), in a melanoma model.