Discordant timing between clinical improvement and changes in neuro‐ophthalmological surrogate markers has frequently been reported in IIH RCTs and real‐world studies, with longitudinal data on Humphrey visual field PMD and OCT measures of RNFL typically demonstrating improvement after a minimum of 12 months of IIH treatment [36, 37]; a fact that may align with the observed reduced risk of papilledema and visual disturbances or blindness with GLP‐1 or GIP/GLP‐1 RA treatment in IIH cohorts with > 12 months of follow‐up [28, 29]. This evidence concerns the gene GCG and optic papillitis.