Despite the robust effects of GLP‐1 RAs on body weight and BMI in T2DM and obesity trials [38, 39], our meta‐analysis did not reveal significant associations between GLP‐1 RAs and BMI reduction, although significant heterogeneity between studies was uncovered with the study by Krajnc et al. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.