IGHG3 and allergic disease: IgG subclasses (IgG1, IgG2, IgG3, and IgG4) perform distinct immunological functions: IgG1 and IgG3 are potent activators of complement and Fc receptor pathways, IgG2 primarily targets polysaccharide antigens, and IgG4 is associated with chronic antigen exposure and tolerance, particularly in allergic diseases [11, 12, 13].