However, increased IFN-γ responses in the lung do not seem to correlate with resistance to infection or improved responses to vaccination and can lead to exacerbated disease (Tameris et al., 2013; Sakai et al., 2016; Leal et al., 2001; Majlessi et al., 2006; Mittrücker et al., 2007). Here, IFNG is linked to infection.