HLA-C and infectious disease: Alongside the evidence for ancient TSP, the MHC region is also notable for its high rate of missense substitutions (dN/dS>1\begin{document}$ dN/dS > 1$\end{document}) (Hughes and Nei, 1988; Hughes and Nei, 1989) and its large number of GWAS hits for autoimmune and infectious diseases (Buniello et al., 2019; Kennedy et al., 2017).