In these cases, the presence of Abs against the thyrotropin receptor (TRAb), mainly in patients with clinical findings, such as exophthalmos, pretibial myxedema, overt hyperthyroidism, diffuse goiter with a “thyroid hell” pattern on Doppler US, and increased uptake on thyroid RI, points more clearly to GBD.28,29. The gene discussed is TSHR; the disease is myxedema.