Five serum autoantibodies are indicative of humoral immunity in LADA: glutamic acid decarboxylase autoantibody (GADA) (one of the most sensitive immunological criteria for diagnosing LADA), pancreatic islet-cell antibodies (ICA), insulinoma associated-2 autoantibodies (IA-2 A), autoantibodies against insulin (IAA), and an association of zinc transporter-8 autoantibody (ZnT8A). The gene discussed is INS; the disease is latent autoimmune diabetes in adults.