MAPT and early-onset autosomal dominant Alzheimer disease: Main neurodegenerative pathologies associated with the most common dementia syndromes include beta-amyloid accumulation and paired helical filament tau (PHF-tau) neurofibrillary tangles in Alzheimer’s disease (AD); Lewy bodies in dementia with Lewy bodies (DLB) and in Parkinson’s disease dementia (PDD); and TDP-43 deposits in the neuropathological changes related to limbic-predominant age-related TDP-43 encephalopathy (LATE) [1].