SYP and central nervous system neoplasm: Synaptophysin is not exclusive to oligodendrogliomas and is expressed in various other CNS tumors, including neurocytomas, which exhibit strong synaptophysin positivity [90]; gangliogliomas, which contain both glial and neuronal components [91]; and dysembryoplastic neuroepithelial tumors (DNETs) [92], which also demonstrate neuronal differentiation, in addition to certain astrocytic tumors, which may show focal synaptophysin expression [93].