CDKN2A and melanoma: The pathophysiology of melanoma is primarily driven by ultraviolet-induced DNA mutations, which play a significant role in melanoma development and are associated with a high mutation burden. Genes associated with a predisposition to melanoma include CDKN2A, CDK4, and MC1R [3]. The risk of metastasis in malignant melanoma is closely associated with the depth of invasion and the presence of ulceration in the primary lesion.