The pathophysiology of melanoma is primarily driven by ultraviolet-induced DNA mutations, which play a significant role in melanoma development and are associated with a high mutation burden. Genes associated with a predisposition to melanoma include CDKN2A, CDK4, and MC1R [3]. The risk of metastasis in malignant melanoma is closely associated with the depth of invasion and the presence of ulceration in the primary lesion. This evidence concerns the gene MC1R and melanoma.