Compared with absent or mild WMH (Fazekas 0–1), Group comparisons revealed that advanced age, hypertension, and abnormal renal function markers [creatinine, cystatin C, β2-microglobulin (β2-MG)] were common risk factors for moderate–severe WMH (all p < 0.0001). This evidence concerns the gene HLA-G and Hypertension.