As one of these abnormal changes, p-Tau, which causes Tau protein to detach from microtubules and to form insoluble tangles, leads to cytoskeletal destabilization in neurons and interferes with the transportation of essential molecules and organelles; Tau protein and p-Tau are strongly associated with cognitive decline and the development of dementia and PD (34). The gene discussed is MAPT; the disease is Mental deterioration.