The mediated proportions of CD6 in the associations between 5 lipids [Sterol ester (27:1/22:6), Phosphatidylcholine (20:4_0:0), Phosphatidylcholine (16:0_20:4), Sphingomyelin (d38:1), Sphingomyelin (d42:2)] and IBD were 4.67%, 3.69%, 4.70%, 4.74%, and 8.65%, respectively (Table 1). The gene discussed is CD6; the disease is inflammatory bowel disease.