We classified the patients with ECRS into 3 groups, as shown inFigure 1, based on the clinical scoring system from the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC).6Kim et al.21reported the upregulation of Th2 mediators such as Th2 cytokines and TSLP in the epithelial cells of patients with moderate or severe ECRS. The gene discussed is TSLP; the disease is chronic rhinosinusitis.