For SA-AKI, Ni et al., demonstrated that NETs are enriched in murine AKI of three distinct sepsis procedures, including CLP, LPS-induced endotoxemia and multidrug-resistant sepsis, and either pharmacological or genetic NETs interruption in combination with Fn14 blockade prolong mice survival and provide renal protection against sepsis (5). This evidence concerns the gene TNFRSF12A and acute kidney injury.