TNFRSF12A and serum lipopolysaccharide activity: For SA-AKI, Ni et al., demonstrated that NETs are enriched in murine AKI of three distinct sepsis procedures, including CLP, LPS-induced endotoxemia and multidrug-resistant sepsis, and either pharmacological or genetic NETs interruption in combination with Fn14 blockade prolong mice survival and provide renal protection against sepsis (5).