Escin, a natural triterpenoid saponin from Aesculus chinensis (Suoluozi), alleviates CUMS-induced depression-like behaviors by modulating both the BDNF/TrkB/CREB and Toll-like receptor 4 (TLR4)/Myeloid differentiation factor 88 (MyD88)/NF-κB signaling pathways (148). The gene discussed is CREB1; the disease is major depressive disorder.