In hypertension complicated with depression, astrocytes trigger neuroinflammatory responses due to mitochondrial damage, and MOOs upregulate Mitofusin 2 (Mfn2) expression, activating mitochondrial autophagy via the PI3K/Akt/mTOR pathway to clear damaged mitochondria in astrocytes (195). Here, AKT1 is linked to depressive symptom measurement.