To determine the effect of NaHS on fibroblast pyroptosis in skin wound tissue, double immunofluorescent staining was used to detect the proteins expression of GSDMD and IL-18 (specific biomarkers for pyroptosis), which showed that GSDMD and IL-18 expressions were increased in the fibroblasts of the DM group as compared with those in the control group. This evidence concerns the gene IL18 and diabetes mellitus.