Studies have found that several members of the USP family regulate the expression of the protein encoded by LSD1.In breast cancer, the deubiquitinating function of USP7 enhances LSD1 protein stability, while CARM1 further enhances USP7’s positive regulation of LSD1 stability by dimethylating the arginine residue at position R838 of LSD1. This evidence concerns the gene KDM1A and breast carcinoma.