To summarize, our unbiased analysis of integrated HNSCC scRNA-seq datasets led to the identification of PRDM6 as a novel TF that governs the type I IFN signaling and immune gene expression and thus promotes proliferation and growth of tumor cells, while PRDM6 itself is also under control of HPV. Here, PRDM6 is linked to head and neck squamous cell carcinoma.