Notably, we identified PRDM6, a histone methyl-transferase (18, 19) previously unlinked to HNSCC, as a key regulator of immune gene expression in HNSCC tumor cells, including canonical interferon-stimulated genes (ISGs) such as ISG15 and IFITM1. This evidence concerns the gene IFITM1 and head and neck squamous cell carcinoma.