Cisplatin (cis-DDP, CDDP) is a platinum-based metal complex antineoplastic agent (100), whose antitumor activity is primarily achieved through forming intra- and interstrand crosslinks with DNA, inducing DNA damage responses, and triggering apoptosis or cell cycle arrest.TRIM37 is involved in promoting malignant progression and cisplatin (CDDP) resistance in gastric cancer, and correlates with tumor recurrence in GC patients after gastrectomy (57). This evidence concerns the gene TRIM37 and gastric cancer.