In the MGC-803 and HGC-27 gastric cancer cell lines, TRIM27 downregulation exerts its effect by first upregulating large tumor suppressor kinase 2 (LATS2), which in turn leads to the inhibition of Yes-associated protein 1 (YAP1), ultimately resulting in the suppression of BIRC5 (48). The gene discussed is YAP1; the disease is gastric cancer.