PRKCD, as a member of the PKC (protein kinase C) family of serine/threonine-specific kinases, interacts with p53 to modulate cisplatin-induced, caspase-3-mediated apoptosis in gastric cancer (99).TRIM69 suppresses drug resistance and metastatic progression in gastric cancer via the TRIM69-PRKCD/BDNF regulatory axis (65). Here, CASP3 is linked to gastric cancer.