In the following decades, the inactivation of the NF2 tumor suppressor gene on chromosome 22, which acts as a master upstream regulator of the Hippo signaling pathway, was recognized as the most common genetic alteration in meningioma oncogenesis and as the genetic alteration responsible for the familial syndrome, neurofibromatosis type 2 (NF2). The gene discussed is NF2; the disease is meningioma.