CD274 and cancer: KEGG pathway enrichment analysis (Figure 4A) revealed that DEGs were significantly enriched in pathways related to interactions between cytokines and their receptors, interactions between viral proteins and cytokines and their receptors, Th1 and Th2 cell differentiation, the NF-κB signaling pathway, the Jak-STAT signaling pathway, PD-L1 expression and PD-1 checkpoint pathways in cancer, chemokine signaling pathways, and T cell receptor signaling pathways.