We also correlated the results obtained with the most common genetic aberrations identified at the diagnosis of BCP-ALL, such as: hyper- hypodiploidy, BCR::ABL1, KMT2A::AFF1, ETV6::RUNX1, TCF3-rearangement, TCF3::PBX1, TCF3::HLF, KMT2A and IKZF1 mutations. The gene discussed is HLF; the disease is acute lymphoblastic leukemia.