At the molecular level, TRIM14 upregulation promotes TRAF3 degradation via NDP52-mediated autophagy, relieving NF-κB pathway inhibition and exacerbating inflammation (35).The recurrence of psoriasis may be closely associated with tissue-resident memory T (Trm) cells persisting within clinically healed lesions. The gene discussed is NFKB1; the disease is psoriasis.