Aberrant hyperactivation of the JAK2/STAT3 axis is frequently observed in TNBC and has been shown to transcriptionally upregulate anti-apoptotic genes such as Bcl-2 and Survivin, facilitate epithelial–mesenchymal transition (EMT), and promote tumor cell migration, invasion, and immune evasion. The gene discussed is BIRC5; the disease is neoplasm.