designed a tri-component micro-nano composite system, CS-6@CPB-S.lux, which integrates gamabufotalin (CS-6), known for its anti-PD-L1 activity, with photothermal carboxy-Prussian blue nanoparticles (CPB NPs) and a tumor-tropic attenuated Salmonella typhimurium strain (S.lux) into a single platform. The gene discussed is CD274; the disease is neoplasm.