STAT3 and neoplasm: Notably, expression of stromal markers such as CCL2 and α-SMA was also diminished, indicating successful remodeling of the tumor microenvironment and restoration of antitumor immunity (31).In addition to the STAT3-centric axis, the JAK1/2–STAT1 pathway is essential for mediating interferon-γ (IFN-γ) signaling, which is crucial for enhancing antigen presentation and initiating effective cytotoxic immune responses.